(+)- Corydaline
(+)- Corydaline
CAS: 518-69-4
Molecular Formula: C22H27NO4
(+)- Corydaline - Names and Identifiers
(+)- Corydaline - Physico-chemical Properties
| Molecular Formula | C22H27NO4 |
| Molar Mass | 369.45 |
| Density | 1.1771 (rough estimate) |
| Melting Point | 135° |
| Boling Point | 499.57°C (rough estimate) |
| Specific Rotation(α) | D20 +311° (c = 0.8 in alc) |
| Solubility | Soluble in chloroform, soluble in ether, slightly soluble in methanol, actually insoluble in water. |
| Appearance | prism crystallization |
| Color | White to Off-White |
| pKa | 6.57±0.40(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
| Refractive Index | 1.5614 (estimate) |
| MDL | MFCD00065280 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Corydalis tubers, Corydalis Koizumi whole grass, deep mountain Corydalis root, Marcha Corydalis tubers and aboveground parts. |
(+)- Corydaline - Risk and Safety
| Toxicity | LD50 in mice (mg/kg): 135.5 ± 12.8 i.v. (Anderson, Chen) |
(+)- Corydaline - Reference
| Reference Show more | 1. Antrum Zenghua, du Lianping. Simultaneous determination of six components in compound yuanhu Zhitong tablets by HPLC [J]. Chinese patent medicine 2017 39(02):312-315. 2. Zhang Dan, Wang Chang-Li, ji diao, et al. Simultaneous determination of five alkaloids in Corydalis yanhusuo by HPLC [J]. Central South pharmacy, 2018, 16(12):1759-1762. 3. Li can, Tang Lijun, Ru Qin, etc. Study on the fingerprint of detoxification drug 1 by high performance liquid chromatography [J]. Journal of Jianghan University (Natural Science Edition), 2018, 46(05):471-476. 4. Zhang, Y., wang, Z., xu, J. et al. Optimization of the extraction and purification of Corydalis yanhusuo W.T. Wang based on the Q-marker uniform design method. BMC Chemistry 14, 9 (2020). https://doi.org/10.1186/s13065-020-00666-6 5. [IF=4.759] Lvhuan Wang et al."Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry."J Chromatogr A. 2018 Aug;1563:135 6. [IF=4.411] Simona S. Ghanem et al."Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity."Molecules. 2021 Jan;26(12):3736 7. [IF=3.963] Zhong-min Zhao et al."Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine."Pestic Biochem Phys. 2019 Sep;159:51 8. [IF=3.373] Xueyan Zhao et al."An integrated strategy for the establishment of a protoberberine alkaloid profile: Exploration of the differences in composition between Tinosporae radix and Fibraurea caulis."Phytochem Analysis. 2021 Nov;32(6):1131-1140 |
(+)- Corydaline - Reference Information
| Overview | Corydalis yanhusuo (Corydalis yanhusuo) is a quaternary amine alkaloid. T.Wang) one of the main active ingredients in tubers. Modern pharmacology shows that Corydalis a not only has analgesic, exciting uterus, anti-arrhythmic effect, Corydalis A has anti-morphine-like effect, can also be used for the preparation of drug detoxification. |
| Application of | Corydalis a can effectively inhibit Virus of the replication of the respiratory tract in a non-toxic range, it can be further developed into a drug for treating or preventing Virus respiratory diseases, and has a wide application prospect. |
| biological activity | Corydaline (( )-Corydaline) is an isoquinoline alkaloid extracted from Corydalis yanhusuo, it is an AChE inhibitor with an IC50 of 226 μm. Corydaline is a μ-opioid receptor (Ki 1.23 µm) agonist that inhibits intestinal Virus 71 (EV71) replication (IC50 25.23 µm). Corydaline has anti-angiogenic, anti-allergic, gastric emptying and antinociceptive effects. |
| Target | IC50: 226 µm (AChE); 25.23 µm (Enterovirus 71) Ki: |
| Cell Line: | Vero cells infected with EV71 |
| Concentration: | 12.5 µM, 25 µM, 50 µM |
| Incubation Time: | 24 hours |
| Result: | Reduced the phosphorylation of P38 MAPK and JNK MAPK and the expression of COX-2. Showed antinociceptive effects in mice. |
| Animal Model: | Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid |
| Dosage: | 10 mg/kg |
| Administration: | Subcutaneous administration; once |
| Use | Corydalis a analgesic, sedative, hypnotic effect. for content determination/identification/pharmacological experiments. Pharmacological Efficacy: analgesic effect. |
Last Update：2024-04-09 20:52:54
Supplier List
Spot supply
Product Name: Corydaline Visit Supplier Webpage Request for quotationCAS: 518-69-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: (+)- Corydaline Visit Supplier Webpage Request for quotationCAS: 518-69-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Corydaline Visit Supplier Webpage Request for quotationCAS: 518-69-4
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: (+)- Corydaline Visit Supplier Webpage Request for quotationCAS: 518-69-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History